Sugi Predict

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SCHEMBL975471

SCHEMBL975471

CC(C)(C)OC(=O)CNC(=O)c1cccc(NS(=O)(=O)CC2CN(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)C2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTPRC P08575 2/20 0.41
▸ EGFR P00533 1/20 0.38
▸ FGFR1 P11362 1/20 0.38
▸ KDR P35968 1/20 0.38
▸ KAT6A Q92794 1/20 0.37
▸ KAT5 Q92993 1/20 0.37
▸ PRMT5 O14744 2/20 0.36
▸ WDR77 Q9BQA1 1/20 0.36
▸ ANO1 Q5XXA6 3/20 0.35
▸ MAPT P10636 1/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP2D6 P10635 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ CCR2 P41597 4/20 0.35
▸ UBE2N P61088 1/20 0.34
▸ SCN9A Q15858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL977096 0.91 DRD2 (0.38) EGFRFGFR1KDRKAT6AKAT5
SCHEMBL3408729 0.89 EGFR (0.40) EGFRFGFR1KDRPRMT5ANO1
SCHEMBL979310 0.88 EGFR (0.39) EGFRFGFR1KDRKMT2AMEN1
SCHEMBL977201 0.87 CCR2 (0.40) EGFRFGFR1KDRKMT2AMEN1
SCHEMBL975803 0.87 EGFR (0.39) EGFRFGFR1KDRPRMT5KMT2A
SCHEMBL975685 0.87 EGFR (0.39) EGFRFGFR1KDRKAT6AKAT5
SCHEMBL975682 0.87 EGFR (0.39) EGFRFGFR1KDRKAT6AKAT5
SCHEMBL3406222 0.86 SCN9A (0.47) EGFRFGFR1KDRMAPTKMT2A
SCHEMBL3405536 0.85 PRMT5 (0.41) EGFRFGFR1KDRPRMT5MAPT
SCHEMBL3408673 0.85 DRD2 (0.40) EGFRFGFR1KDRSCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2234966-B1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI SA (FR) 2013-09-11 — — EP claimed
US-8445478-B2 Azetidine derivatives, their preparation and their application in therapy SANOFI (FR) 2013-05-21 — — US claimed
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI-AVENTIS (FR) 2011-01-13 — — US claimed
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI (FR) 2013-09-12 — — US disclosed
US-8445478-B2 Azetidine derivatives, their preparation and their application in therapy SANOFI (FR) 2013-05-21 — — US disclosed
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI-AVENTIS (FR) 2011-01-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY QDPR, AZI2, ADRA1B PTPRC 1120/4885EGFR 661/4885FGFR1 3835/4885
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY QDPR, AZI2, ADRA1B PTPRC 1120/4885EGFR 661/4885FGFR1 3835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.