Sugi Predict

Sugi Predict / Compounds / SCHEMBL975685

SCHEMBL975685

SCHEMBL975685

CC(NC(=O)c1cccc(NS(=O)(=O)CC2CN(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)C2)c1)C(=O)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 5/20 0.39
▸ FGFR1 P11362 5/20 0.39
▸ KDR P35968 5/20 0.39
▸ MAPT P10636 3/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ ATM Q13315 1/20 0.37
▸ CCR2 P41597 1/20 0.36
▸ KAT6A Q92794 1/20 0.36
▸ KAT5 Q92993 1/20 0.36
▸ ANO1 Q5XXA6 2/20 0.35
▸ HPGD P15428 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ MAP3K5 Q99683 1/20 0.34
▸ UTS2R Q9UKP6 2/20 0.34
▸ LMNA P02545 2/20 0.34
▸ ACKR3 P25106 1/20 0.34
▸ TP53 P04637 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ CTSD P07339 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL975682 1.00 EGFR (0.39) EGFRFGFR1KDRMAPTMAPK1
SCHEMBL977630 0.89 KAT5 (0.37) MAPTMAPK1ATMCCR2KAT6A
SCHEMBL977633 0.89 KAT5 (0.37) MAPTMAPK1ATMCCR2KAT6A
SCHEMBL976524 0.88 EGFR (0.40) EGFRFGFR1KDRCCR2MAP3K5
SCHEMBL976523 0.88 EGFR (0.40) EGFRFGFR1KDRCCR2MAP3K5
SCHEMBL976385 0.88 EGFR (0.40) EGFRFGFR1KDRCCR2HPGD
SCHEMBL977764 0.88 CCR2 (0.40) EGFRFGFR1KDRCCR2MAP3K5
SCHEMBL976516 0.88 EGFR (0.40) EGFRFGFR1KDRCCR2HPGD
SCHEMBL975471 0.87 PTPRC (0.41) EGFRFGFR1KDRMAPTCCR2
SCHEMBL975468 0.86 KAT6A (0.35) EGFRFGFR1KDRKAT6AKAT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2234966-B1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI SA (FR) 2013-09-11 — — EP claimed
US-8445478-B2 Azetidine derivatives, their preparation and their application in therapy SANOFI (FR) 2013-05-21 — — US claimed
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI-AVENTIS (FR) 2011-01-13 — — US claimed
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI (FR) 2013-09-12 — — US disclosed
US-8445478-B2 Azetidine derivatives, their preparation and their application in therapy SANOFI (FR) 2013-05-21 — — US disclosed
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI-AVENTIS (FR) 2011-01-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY QDPR, AZI2, ADRA1B EGFR 661/4885FGFR1 3835/4885KDR 2053/4885
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY QDPR, AZI2, ADRA1B EGFR 661/4885FGFR1 3835/4885KDR 2053/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.