Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9755394 | 0.94 | POLB (0.44) | POLBRAD52HDAC3APPACHE | |
| SCHEMBL9755331 | 0.86 | ACHE (0.39) | POLBRAD52ACHEMAPTKDM1A | |
| SCHEMBL9755411 | 0.83 | POLB (0.47) | POLBRAD52HDAC3APPACHE | |
| SCHEMBL9755373 | 0.79 | ACHE (0.39) | POLBRAD52ACHEMAPTKDM1A | |
| SCHEMBL9755334 | 0.79 | ACHE (0.38) | POLBRAD52ACHEMAPTKDM1A | |
| SCHEMBL9755340 | 0.79 | ACHE (0.38) | POLBRAD52ACHEMAPTKDM1A | |
| SCHEMBL9755410 | 0.78 | KDM1A (0.41) | POLBRAD52MAPTNPC1PDGFRB | |
| SCHEMBL9755402 | 0.74 | KDM1A (0.43) | POLBRAD52MAPTNPC1PDGFRB | |
| SCHEMBL9755378 | 0.74 | KDM1A (0.44) | POLBRAD52MAPTNPC1PDGFRB | |
| SCHEMBL9755466 | 0.72 | KDM1A (0.42) | POLBRAD52ACHEMAPTNUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |