Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9755351 | 0.89 | KDM1A (0.50) | POLBRAD52NUDT1KDM1AKMT2A | |
| SCHEMBL9755466 | 0.89 | KDM1A (0.42) | POLBRAD52TOP2ATOP2BNUDT1 | |
| SCHEMBL9755333 | 0.84 | KDM1A (0.51) | POLBRAD52TOP2ATOP2BKDM1A | |
| SCHEMBL9755327 | 0.81 | POLB (0.50) | POLBRAD52TOP2ATOP2BKDM1A | |
| SCHEMBL9755413 | 0.77 | TOP2A (0.50) | POLBRAD52TOP2ATOP2BKDM1A | |
| SCHEMBL9755390 | 0.76 | TOP2A (0.55) | POLBRAD52TOP2ATOP2BKDM1A | |
| SCHEMBL9755321 | 0.74 | ACHE (0.47) | TOP2ATOP2BKDM1AKMT2AACHE | |
| SCHEMBL9755411 | 0.73 | POLB (0.47) | POLBRAD52TOP2ATOP2BNUDT1 | |
| SCHEMBL9755394 | 0.73 | POLB (0.44) | POLBRAD52NUDT1KDM1AMAP2K1 | |
| SCHEMBL9593647 | 0.72 | KDM1A (0.50) | POLBKDM1AMAP2K1EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |