Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9756730 | 0.87 | FOLH1 (0.49) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9756722 | 0.85 | LMNA (0.52) | SGMS2ALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL22568217 | 0.77 | NPC1 (0.56) | SGMS2ALDH1A1MAPTNPC1GAA | |
| SCHEMBL16015328 | 0.76 | MAPT (0.57) | ALDH1A1MAPTNPC1GAASMN1; SMN2 | |
| SCHEMBL22441038 | 0.75 | MAPT (0.55) | SGMS2ALDH1A1MAPTNPC1GAA | |
| SCHEMBL6748166 | 0.74 | SGMS2 (0.72) | SGMS2ALDH1A1MAPTNPC1GAA | |
| SCHEMBL22568219 | 0.72 | MCL1 (0.57) | SGMS2ALDH1A1MAPTNPC1GAA | |
| SCHEMBL2743027 | 0.72 | ATM (0.51) | ALDH1A1MAPTGAASMN1; SMN2LMNA | |
| SCHEMBL23067188 | 0.72 | HDAC6 (0.51) | SGMS2ALDH1A1MAPTNPC1GAA | |
| SCHEMBL29557588 | 0.72 | HDAC6 (0.51) | SGMS2ALDH1A1MAPTNPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5077432-A | Monobactam hydrazides containing catechol sulfonic acid groups | E. R. SQUIBB & SONS, INC. (US) | 1991-12-31 | — | — | US | disclosed |
| EP-0438752-A1 | Monobactam hydrazides containing catechol sulfonic acid groups | E.R. SQUIBB & SONS, INC. (US) | 1991-07-31 | — | — | EP | disclosed |
| US-5030724-A | Monobactam hydrazides containing catechol sulfonic acid groups | E. R. SQUIBB & SONS, INC. (US) | 1991-07-09 | — | — | US | disclosed |