Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9756774 | 1.00 | STAT3 (0.43) | STAT3ALDH1A1MEN1KMT2ADHODH | |
| SCHEMBL13104829 | 1.00 | STAT3 (0.43) | STAT3ALDH1A1MEN1KMT2ADHODH | |
| SCHEMBL2176311 | 0.90 | GAA (0.45) | STAT3ALDH1A1MEN1KMT2ADHODH | |
| SCHEMBL4202226 | 0.85 | CA2 (0.41) | STAT3ALDH1A1MEN1KMT2ADHODH | |
| SCHEMBL6431507 | 0.85 | CA2 (0.41) | STAT3ALDH1A1MEN1KMT2ADHODH | |
| SCHEMBL4202231 | 0.85 | CA2 (0.41) | STAT3ALDH1A1MEN1KMT2ADHODH | |
| SCHEMBL13096089 | 0.84 | STAT3 (0.41) | STAT3ALDH1A1MEN1KMT2ADHODH | |
| SCHEMBL6069092 | 0.84 | STAT3 (0.41) | STAT3ALDH1A1MEN1KMT2ADHODH | |
| SCHEMBL4621606 | 0.83 | STAT3 (0.43) | STAT3ALDH1A1MEN1KMT2ADHODH | |
| SCHEMBL2548351 | 0.83 | STAT3 (0.43) | STAT3ALDH1A1MEN1KMT2ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780336-B1 | STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN | PASTEUR INSTITUT (FR) | 2017-07-19 | — | — | EP | disclosed |
| US-9598393-B2 | Structural variants of mycolactones for use in modulating inflammation, immunity and pain | INSTITUT PASTEUR (FR) | 2017-03-21 | — | — | US | disclosed |
| US-20140329771-A1 | STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN | INSTITUT PASTEUR (FR) | 2014-11-06 | — | — | US | disclosed |
| EP-2780336-A1 | STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN | Institut Pasteur (FR) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072896-A1 | STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN | INSTITUT PASTEUR (FR) | 2013-05-23 | — | — | WO | disclosed |
| EP-2594561-A1 | Structural variants of mycolactones for use in modulating inflammation, immunity and pain | INSTITUT PASTEUR (FR) | 2013-05-22 | — | — | EP | disclosed |
| EP-0316374-B1 | OPTICALLY ACTIVE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-07-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329771-A1 | STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN | IL1B, MYC, IL1A | STAT3 570/4885ALDH1A1 2781/4885MEN1 1200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.