Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 3/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404048 | 0.84 | ALDH1A1 (0.36) | CYP11B1CYP11B2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL1003836 | 0.84 | CYP11B1 (0.34) | CYP11B1CYP11B2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7437163 | 0.82 | ALDH1A1 (0.31) | ALDH1A1CYP1A2CYP2D6HPGDHIF1A | |
| SCHEMBL7415167 | 0.81 | ALDH1A1 (0.34) | CYP11B1CYP11B2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9756933 | 0.81 | MEN1 (0.37) | CYP11B1CYP11B2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7534704 | 0.80 | HIF1A (0.37) | ALDH1A1CYP1A2CYP2D6HPGDHIF1A | |
| SCHEMBL7434512 | 0.78 | ATP4A (0.32) | CYP11B1CYP11B2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL10439558 | 0.78 | CYP1A2 (0.44) | CYP11B1CYP11B2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9585649 | 0.77 | TAAR1 (0.35) | TAAR1CYP11B1CYP11B2KIF11SMN1; SMN2 | |
| SCHEMBL643809 | 0.75 | CYP11B1 (0.37) | CYP11B1CYP11B2ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863271-B2 | 2-aminobenzoxazole carboxamides as 5HT3 modulators | ALBANY MOLECULAR RESEARCH, INC. (US) | 2011-01-04 | — | — | US | disclosed |
| EP-2061460-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | Albany Molecular Research, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| US-20080255114-A1 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | AMR TECHNOLOGY, INC. (US) | 2008-10-16 | — | — | US | disclosed |
| WO-2008019372-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-02-14 | — | — | WO | disclosed |
| US-5932606-A | Pyrazinone, pyridinone, piperidine and pyrrolidine thrombin inhibitors | MERCK & CO., INC. (US) | 1999-08-03 | — | — | US | disclosed |
| US-5223625-A | Antagonistic acitivity on 5-hydroxytryptamine receptors | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1993-06-29 | — | — | US | disclosed |
| US-4985424-A | Certain substituted 1,7-annelated 1h-indazoles being selective antagonists of 5-ht-receptors | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-01-15 | — | — | US | disclosed |
| US-4950759-A | ANTAGONISTS OF NEURONAL 5-HYDROXYTRYPTAMINE(5-HT) RECEPTORS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1990-08-21 | — | — | US | disclosed |
| EP-0377238-A1 | New annelated indolo (3,2-c)-lactams | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255114-A1 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | HTR3E, HTR3C, HTR3A | TAAR1 1071/4885CYP11B1 3454/4885CYP11B2 2858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.