Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757224 | 0.90 | EDNRA (0.48) | EDNRATBXAS1NPC1 | |
| SCHEMBL9757151 | 0.90 | NR4A2 (0.43) | EDNRANR4A2RXRARXRBRXRG | |
| SCHEMBL9757716 | 0.85 | ALOX5AP (0.48) | EDNRASLC26A4KMT2AALOX5APCYP3A4 | |
| SCHEMBL9757150 | 0.82 | CYSLTR1 (0.43) | EDNRASLC26A4KMT2ATBXAS1ALOX5AP | |
| SCHEMBL9757075 | 0.81 | ROCK1 (0.32) | SLC26A4KMT2AALOX5APCYP3A4KCNH2 | |
| SCHEMBL9757206 | 0.79 | NR4A2 (0.42) | KMT2ANR4A2RXRARXRBRXRG | |
| SCHEMBL9757078 | 0.75 | CYSLTR1 (0.53) | — | |
| SCHEMBL9757054 | 0.74 | PDE10A (0.58) | EDNRAALOX5AP | |
| SCHEMBL9757226 | 0.72 | EDNRA (0.48) | EDNRAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9757227 | 0.72 | EDNRA (0.48) | EDNRAKMT2ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |