Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757147 | 0.90 | EDNRA (0.42) | EDNRANPC1TBXAS1 | |
| SCHEMBL9757054 | 0.85 | PDE10A (0.58) | EDNRACYSLTR1PDE10AGPBAR1ALOX5 | |
| SCHEMBL9757226 | 0.82 | EDNRA (0.48) | EDNRACYSLTR1PDE10ANPC1MAPT | |
| SCHEMBL9757227 | 0.82 | EDNRA (0.48) | EDNRACYSLTR1PDE10ANPC1MAPT | |
| SCHEMBL9757151 | 0.81 | NR4A2 (0.43) | EDNRACYSLTR1GPBAR1TBXAS1 | |
| SCHEMBL9757076 | 0.80 | ALOX5 (0.59) | EDNRACYSLTR1PDE10AGPBAR1ALOX5 | |
| SCHEMBL9757119 | 0.77 | PDE10A (0.54) | CYSLTR1PDE10AGPBAR1ALOX5 | |
| SCHEMBL9757233 | 0.76 | CYSLTR1 (0.55) | CYSLTR1PDE10AGPBAR1ALOX5 | |
| SCHEMBL9757716 | 0.74 | ALOX5AP (0.48) | EDNRACYSLTR1PDE10AALOX5 | |
| SCHEMBL9757124 | 0.72 | ALOX5 (0.58) | CYSLTR1PDE10AGPBAR1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |