Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.48 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757054 | 0.89 | PDE10A (0.58) | ALOX5APEDNRACYSLTR1CYSLTR2PDE10A | |
| SCHEMBL9757150 | 0.86 | CYSLTR1 (0.43) | ALOX5APEDNRACYSLTR1CYSLTR2SLC26A4 | |
| SCHEMBL9757147 | 0.85 | EDNRA (0.42) | ALOX5APEDNRASLC26A4KMT2ACYP3A4 | |
| SCHEMBL9757076 | 0.82 | ALOX5 (0.59) | EDNRACYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL9757101 | 0.81 | CYSLTR1 (0.46) | ALOX5APCYSLTR1CYSLTR2PDE10A | |
| SCHEMBL9757119 | 0.81 | PDE10A (0.54) | ALOX5APCYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL9757233 | 0.80 | CYSLTR1 (0.55) | ALOX5APCYSLTR1PDE10AALOX5 | |
| SCHEMBL9757078 | 0.79 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2 | |
| SCHEMBL9757151 | 0.78 | NR4A2 (0.43) | EDNRACYSLTR1CYSLTR2 | |
| SCHEMBL9757226 | 0.75 | EDNRA (0.48) | EDNRACYSLTR1CYSLTR2PDE10AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |