Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 6/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.42 |
| ▸ | HTR3B | O95264 | 3/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8940279 | 0.94 | MEN1 (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Maleic Acid SCHEMBL10482709 | 0.80 | KDM4E (0.48) | KDM4EHTR3A | |
| SCHEMBL8939998 | 0.73 | PKM (0.52) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9201788 | 0.71 | MEN1 (0.55) | MEN1KMT2A | |
| SCHEMBL7276361 | 0.70 | HTR3A (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7270849 | 0.70 | HTR3A (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7269268 | 0.70 | HTR3A (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7270520 | 0.70 | HTR3A (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7269216 | 0.70 | HTR3A (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7269263 | 0.70 | HTR3A (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997956-A | Analgesics | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |