SCHEMBL975877

SCHEMBL975877

Cc1cc(O)c(C(=O)O)cc1C

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.66
GRM1 Q13255 1/20 0.58
MCL1 Q07820 4/20 0.57
CSNK2A1 P68400 1/20 0.56
KDM4E B2RXH2 4/20 0.52
HPGD P15428 3/20 0.52
HSD17B10 Q99714 3/20 0.52
GAA P10253 2/20 0.52
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
CA12 O43570 2/20 0.48
CA7 P43166 2/20 0.48
CA9 Q16790 2/20 0.48
CA14 Q9ULX7 2/20 0.48
PTGS2 P35354 2/20 0.48
ALOX5 P09917 1/20 0.48
TSHR P16473 1/20 0.48
MYC P01106 1/20 0.46
KLKB1 P03952 1/20 0.46
CTSB P07858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17171674 0.88 GRM1 (0.56) ALDH1A1GRM1MCL1CSNK2A1KDM4E
SCHEMBL4893830 0.88 GRM1 (0.56) ALDH1A1GRM1MCL1CSNK2A1KDM4E
SCHEMBL27289129 0.88 CSNK2A1 (0.54) ALDH1A1GRM1MCL1CSNK2A1KDM4E
SCHEMBL3835073 0.88 CSNK2A1 (0.54) ALDH1A1GRM1MCL1CSNK2A1KDM4E
SCHEMBL27543301 0.86 CSNK2A1 (0.52) ALDH1A1GRM1MCL1CSNK2A1KDM4E
SCHEMBL14213141 0.86 GRM1 (0.55) ALDH1A1GRM1MCL1CSNK2A1KDM4E
SCHEMBL30442476 0.84 KDM4E (0.54) ALDH1A1GRM1MCL1CSNK2A1KDM4E
SCHEMBL235710 0.84 KDM4E (0.54) ALDH1A1GRM1MCL1CSNK2A1KDM4E
SCHEMBL2142147 0.83 ALDH1A1 (0.53) ALDH1A1GRM1MCL1CSNK2A1KDM4E
SCHEMBL167694 0.82 GRM1 (0.51) ALDH1A1GRM1MCL1CSNK2A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12076316-B2 Levorphanol prodrugs and processes for making and using them ZEVRA THERAPEUTICS INC. 2024-09-03 US claimed
US-20220096463-A1 LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM ALTER DOMUS (US) LLC 2022-03-31 US claimed
CN-108601347-B Composition for crop care and protection 阿尔法生物农药有限公司 2022-03-11 CN claimed
US-11234975-B2 Levorphanol prodrugs and processes for making and using them KEMPHARM, INC. (US) 2022-02-01 US claimed
US-20200390757-A1 LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM ALTER DOMUS (US) LLC 2020-12-17 US claimed
WO-2018191474-A1 LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM KEMPHARM, INC. (US) 2018-10-18 WO claimed
CN-108601347-A The composition nursed and protected for crop 阿尔法生物农药有限公司 2018-09-28 CN claimed
US-20170312270-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF ALTER DOMUS (US) LLC 2017-11-02 US claimed
CN-107261148-A Methylphenidate prodrug, its preparation and application 凯姆制药公司 2017-10-20 CN claimed
EP-3226907-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS AND MAKING AND USE THEREOF Kempharm, Inc. (US) 2017-10-11 EP claimed
EP-2771002-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF Kempharm, Inc. (US) 2014-09-03 EP claimed
EP-2736510-A2 METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME Kempharm, Inc. (US) 2014-06-04 EP claimed
CN-103826633-A Methylphenidate prodrugs, methods of making and using the same KEMPHARM INC 2014-05-28 CN claimed
US-20130150395-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF KEMPHARM, INC. (US) 2013-06-13 US claimed
WO-2013063204-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF KEMPHARM, INC. (US) 2013-05-02 WO claimed
WO-2013016668-A2 METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME KEMPHARM INC. (US) 2013-01-31 WO claimed
US-20120142719-A1 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof ALTER DOMUS (US) LLC 2012-06-07 US claimed
CN-102480959-A Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof KEMPHARM INC 2012-05-30 CN claimed
EP-2448407-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF Kempharm, Inc. (US) 2012-05-09 EP claimed
US-20110002990-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF ALTER DOMUS (US) LLC 2011-01-06 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200390757-A1 LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM OPRM1, OPRL1, OPRK1 ALDH1A1 1258/4885GRM1 932/4885MCL1 4324/4885
US-20170312270-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF OPRM1, OPRK1, OPRD1 ALDH1A1 125/4885GRM1 663/4885MCL1 4633/4885
US-12076316-B2 Levorphanol prodrugs and processes for making and using them OPRM1, OPRL1, OPRK1 ALDH1A1 1258/4885GRM1 932/4885MCL1 4324/4885
US-11234975-B2 Levorphanol prodrugs and processes for making and using them OPRM1, OPRL1, OPRK1 ALDH1A1 1258/4885GRM1 932/4885MCL1 4324/4885
US-20110002990-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF CYP2B6, CYP3A43, CYP2D6 ALDH1A1 160/4885GRM1 1233/4885MCL1 3072/4885
US-20120142719-A1 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof CYP2B6, CYP3A43, CYP2D6 ALDH1A1 160/4885GRM1 1233/4885MCL1 3072/4885
US-20130150395-A1 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF OPRM1, OPRK1, CYP2D6 ALDH1A1 92/4885GRM1 608/4885MCL1 3460/4885
US-20220096463-A1 LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM OPRM1, OPRL1, OPRK1 ALDH1A1 1258/4885GRM1 932/4885MCL1 4324/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.