Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.37 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.37 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10582405 | 0.89 | GAA (0.40) | SIRT6FGFR1GRIK1GRIA1GRIA2 | |
| SCHEMBL9760013 | 0.78 | ADORA3 (0.42) | CA12CA9 | |
| SCHEMBL9194076 | 0.77 | ROCK2 (0.42) | PRMT5WDR77FGFR1PARP1CA12 | |
| SCHEMBL8916747 | 0.77 | TBXAS1 (0.45) | FGFR1CA12CA9IDO1MEN1 | |
| SCHEMBL9190610 | 0.76 | HTR5A (0.38) | FGFR1GRIK1GRIA1GRIA2GRIA3 | |
| SCHEMBL9285801 | 0.75 | IP6K1 (0.51) | PARP1CA12CA9CHEK1 | |
| SCHEMBL669278 | 0.74 | KDM4E (0.46) | PARP1KDM4EGRIK1GRIA1GRIA2 | |
| SCHEMBL9077581 | 0.73 | IDO1 (0.47) | FGFR1IDO1MEN1ALDH1A1LMNA | |
| SCHEMBL9836179 | 0.73 | IDO1 (0.53) | IDO1MEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL9663508 | 0.72 | IDO1 (0.37) | FGFR1IDO1MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037829-A | Antitumor Activity; Androgen, Estrogen Inhibitors; Suppress The Plasma Elimination Of Retinoids | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-06 | — | — | US | disclosed |