Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 9/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9759900 | 0.89 | ADRB1 (0.52) | F10ADRB1HRH3HRH2HRH1 | |
| SCHEMBL9760771 | 0.80 | F10 (0.49) | F10ITGB3ITGA2B | |
| SCHEMBL9760074 | 0.80 | DRD2 (0.55) | F10 | |
| SCHEMBL5632390 | 0.80 | ALDH1A1 (0.45) | F10HRH3HRH2HRH1IKBKB | |
| SCHEMBL5631650 | 0.79 | ALDH1A1 (0.56) | F10HRH3HRH1 | |
| SCHEMBL5633362 | 0.79 | ALDH1A1 (0.54) | F10ADRB1HRH3HRH2HRH1 | |
| SCHEMBL6576136 | 0.79 | CYP3A4 (0.47) | F10 | |
| SCHEMBL5633359 | 0.79 | ALDH1A1 (0.54) | F10ADRB1HRH3HRH2HRH1 | |
| SCHEMBL7113722 | 0.78 | F10 (0.55) | F10HRH3HRH2HRH1 | |
| SCHEMBL7113715 | 0.78 | F10 (0.55) | F10HRH3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |