Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.52 |
| ▸ | F10 | P00742 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9761013 | 0.89 | F10 (0.47) | ADRB1F10HRH2HRH1HRH3 | |
| SCHEMBL9760149 | 0.82 | IDO1 (0.45) | ADRB1KCNH2JAK2JAK3ADRB2 | |
| SCHEMBL9760074 | 0.82 | DRD2 (0.55) | F10SMN1; SMN2 | |
| SCHEMBL5632390 | 0.81 | ALDH1A1 (0.45) | F10NPC1ARHRH2HRH1 | |
| SCHEMBL6576136 | 0.81 | CYP3A4 (0.47) | F10ARSMN1; SMN2 | |
| SCHEMBL5633362 | 0.81 | ALDH1A1 (0.54) | ADRB1F10HRH2HRH1HRH3 | |
| SCHEMBL5633359 | 0.81 | ALDH1A1 (0.54) | ADRB1F10HRH2HRH1HRH3 | |
| SCHEMBL5631650 | 0.81 | ALDH1A1 (0.56) | F10NPC1SMN1; SMN2HRH1HRH3 | |
| SCHEMBL9760771 | 0.80 | F10 (0.49) | F10HPGD | |
| SCHEMBL9759732 | 0.80 | ADRB1 (0.43) | ADRB1KCNH2JAK2JAK3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | claimed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | claimed |
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |