Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 2/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764011 | 1.00 | GPR119 (0.39) | GPR119ATMKLK7STSKLK5 | |
| SCHEMBL31486499 | 0.85 | CTSL (0.44) | KLK7STSKLK5 | |
| SCHEMBL10434897 | 0.84 | HSD17B2 (0.39) | GPR119KLK7STSKLK5KMT2A | |
| SCHEMBL9763248 | 0.83 | ACE (0.42) | GPR119KLK7STSKLK5KMT2A | |
| SCHEMBL12824561 | 0.81 | HSD17B10 (0.36) | GPR119KLK7KLK5KDM4EHSD17B10 | |
| SCHEMBL9763782 | 0.80 | HTRA1 (0.34) | GPR119KLK7KLK5HTRA1HSD17B10 | |
| SCHEMBL9763781 | 0.80 | HTRA1 (0.34) | GPR119KLK7KLK5HTRA1HSD17B10 | |
| SCHEMBL7703731 | 0.79 | P2RX3 (0.39) | GPR119KLK7KLK5KMT2A | |
| SCHEMBL9763156 | 0.79 | TPSAB1 (0.35) | GPR119KLK7STSKLK5KMT2A | |
| SCHEMBL9763153 | 0.79 | TPSAB1 (0.35) | GPR119KLK7STSKLK5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021439-A | Senile dementia and memory dysfunction | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0367393-A2 | New heterocyclic compounds, production and use thereof | Takeda Chemical Industries, Ltd. (JP) | 1990-05-09 | — | — | EP | disclosed |