⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764526 | 0.79 | GPR84 (0.33) | — | |
| SCHEMBL9764724 | 0.75 | GPR84 (0.41) | — | |
| SCHEMBL9764661 | 0.75 | GPR84 (0.41) | — | |
| SCHEMBL10506484 | 0.69 | GPR84 (0.53) | — | |
| SCHEMBL2840978 | 0.68 | SHBG (0.35) | — | |
| SCHEMBL12965485 | 0.67 | SHBG (0.36) | — | |
| SCHEMBL170961 | 0.67 | SHBG (0.39) | — | |
| SCHEMBL9716381 | 0.66 | SHBG (0.32) | — | |
| SCHEMBL3421946 | 0.66 | SHBG (0.41) | — | |
| SCHEMBL4490677 | 0.66 | SHBG (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041694-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1991-08-20 | — | — | US | disclosed |
| US-4965373-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1990-10-23 | — | — | US | disclosed |
| US-4895973-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & COMPANY (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0194610-B1 | SUBSTITUTED GLUTARIC ACID LACTONES IN THE TREATMENT OF HYPERLIPIDEMIA | G.D. Searle & Co. (US) | 1989-02-22 | — | — | EP | disclosed |
| US-4622338-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0194610-A1 | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G.D. Searle & Co. (US) | 1986-09-17 | — | — | EP | disclosed |