Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9763258 | 0.91 | SIGMAR1 (0.50) | SIGMAR1MAOACHRM2MAPTBCHE | |
| SCHEMBL9763777 | 0.90 | SIGMAR1 (0.49) | SIGMAR1MAOACHRM2MAPTBCHE | |
| SCHEMBL24641663 | 0.83 | MAPT (0.57) | SIGMAR1MAPTBCHEL3MBTL1RAB9A | |
| SCHEMBL10477755 | 0.83 | SIGMAR1 (0.69) | SIGMAR1MAOACHRM2MAPTBCHE | |
| SCHEMBL9764394 | 0.83 | SIGMAR1 (0.69) | SIGMAR1MAOACHRM2MAPTBCHE | |
| Hydrochloric Acid SCHEMBL9258435 | 0.81 | SIGMAR1 (0.67) | SIGMAR1MAOACHRM2MAPTBCHE | |
| SCHEMBL9764418 | 0.81 | SLC13A5 (0.47) | MAPTL3MBTL1ASAH1RAB9ASMN1; SMN2 | |
| SCHEMBL10898026 | 0.79 | L3MBTL1 (0.46) | SIGMAR1MAOACHRM2MAPTBCHE | |
| SCHEMBL10464983 | 0.78 | CHRM2 (0.59) | SIGMAR1MAOACHRM2BCHE | |
| SCHEMBL27716955 | 0.78 | SIGMAR1 (0.58) | SIGMAR1MAOACHRM2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| EP-0181709-B1 | DICHLOROANILINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-05-09 | — | — | EP | disclosed |
| EP-0181709-A1 | Dichloroaniline Derivatives | GLAXO GROUP LIMITED (GB) | 1986-05-21 | — | — | EP | disclosed |