Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.47 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21382093 | 0.82 | SMN1; SMN2 (0.55) | SLC13A5MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9764527 | 0.81 | SIGMAR1 (0.48) | ASAH1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9764440 | 0.78 | SLC13A5 (0.52) | SLC13A5MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9764494 | 0.77 | GSK3B (0.46) | SLC13A5MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2755879 | 0.74 | ERCC1 (0.58) | SLC13A5MAPTHDAC1SMN1; SMN2NPC1 | |
| SCHEMBL10488193 | 0.74 | SLC13A5 (0.52) | SLC13A5ASAH1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL9764529 | 0.73 | L3MBTL1 (0.45) | SLC13A5MAPTSMN1; SMN2L3MBTL1FFAR4 | |
| SCHEMBL9764710 | 0.72 | SLC13A5 (0.42) | SLC13A5MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10488261 | 0.72 | GSK3B (0.46) | SLC13A5MAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL9764333 | 0.71 | SLC2A1 (0.46) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |