Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP12 | P39900 | 2/20 | 0.35 |
| ▸ | CETP | P11597 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | BCHE | P06276 | 3/20 | 0.32 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764538 | 0.85 | HPGD (0.35) | HPGDTP53MMP2MMP12POLB | |
| SCHEMBL9764279 | 0.75 | NR1H3 (0.35) | MMP2MMP12BCHEACHEKDM4E | |
| SCHEMBL10466598 | 0.74 | MMP13 (0.34) | MEN1KMT2ABCHEACHEKDM4E | |
| SCHEMBL10468372 | 0.71 | NR1H3 (0.33) | BCHEACHEKDM4EMAPTMAPK1 | |
| SCHEMBL9764569 | 0.70 | SNCA (0.38) | HPGDKMT2AACACB | |
| SCHEMBL9764548 | 0.69 | KCNH2 (0.33) | BCHEACHEKDM4E | |
| SCHEMBL9764422 | 0.69 | LTA4H (0.37) | POLBMEN1KMT2AKDM4EMAPT | |
| SCHEMBL10465464 | 0.69 | MAOB (0.32) | BCHEACHE | |
| SCHEMBL10466933 | 0.67 | NR1H3 (0.36) | MEN1KMT2ABCHEACHEKDM4E | |
| SCHEMBL10466931 | 0.67 | NR1H3 (0.33) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| EP-0181709-A1 | Dichloroaniline Derivatives | GLAXO GROUP LIMITED (GB) | 1986-05-21 | — | — | EP | disclosed |