Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764833 | 0.83 | ALOX5 (0.43) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL9764837 | 0.82 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9764870 | 0.81 | ALDH1A1 (0.38) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9764820 | 0.80 | ALOX5 (0.45) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9764853 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL10559630 | 0.76 | ALOX5 (0.42) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9764866 | 0.75 | ALOX5 (0.43) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL15858582 | 0.73 | MAPT (0.40) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL19768715 | 0.73 | GPR3 (0.56) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9764852 | 0.72 | PLA2G10 (0.40) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |