Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | ECE1 | P42892 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | IL2 | P60568 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764922 | 0.84 | ALOX5 (0.49) | ALOX5NPC1RAB9ACYP1A2CYP2D6 | |
| SCHEMBL9764809 | 0.77 | PLA2G10 (0.40) | ALOX5CYP1A2CYP2D6CYP2C19MMP12 | |
| SCHEMBL10561801 | 0.77 | CYP1A2 (0.51) | ALOX5NPC1RAB9ACYP1A2CYP2D6 | |
| SCHEMBL9764825 | 0.74 | SLC9A1 (0.33) | ALOX5DYRK1A | |
| SCHEMBL9764888 | 0.74 | ALOX5 (0.75) | ALOX5MAOA | |
| SCHEMBL9764839 | 0.73 | ECE1 (0.44) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10563244 | 0.72 | ALOX5 (0.45) | ALOX5 | |
| SCHEMBL9764821 | 0.71 | KMT2A (0.45) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9764815 | 0.70 | GPR35 (0.43) | ALOX5RAB9AKMT2AMEN1 | |
| SCHEMBL9764895 | 0.70 | NPC1 (0.47) | ALOX5NPC1RAB9ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |