Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9765058 | 0.91 | TP53 (0.46) | EGFRERBB2TP53ALDH1A1NPSR1 | |
| SCHEMBL10430182 | 0.87 | EGFR (0.40) | EGFRERBB2ALDH1A1NPSR1TRPV1 | |
| SCHEMBL9765053 | 0.82 | NPSR1 (0.43) | EGFRERBB2ALDH1A1NPSR1SLC6A2 | |
| SCHEMBL9765050 | 0.82 | SOAT1 (0.51) | ALDH1A1NPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9765032 | 0.77 | MMP1 (0.48) | ALDH1A1 | |
| SCHEMBL8810460 | 0.75 | PTGES (0.53) | EGFRERBB2ALDH1A1NPSR1 | |
| SCHEMBL9765051 | 0.74 | TP53 (0.43) | TP53ALDH1A1NPSR1SLC6A2SLC6A4 | |
| SCHEMBL9784544 | 0.74 | EGFR (0.52) | EGFRERBB2ALDH1A1NPSR1MAPT | |
| SCHEMBL6803071 | 0.73 | UBE2M (0.46) | TP53ALDH1A1NPSR1KMT2ALMNA | |
| SCHEMBL6808919 | 0.72 | SOAT1 (0.50) | MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994465-A | Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds | WARNER-LAMBERT COMPANY (US) | 1991-02-19 | — | — | US | claimed |
| EP-0384320-A1 | Antihyperlipidemic and anti-atherosclerotic trisubstituted urea compounds | WARNER-LAMBERT COMPANY (US) | 1990-08-29 | — | — | EP | claimed |
| US-4994465-A | Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds | WARNER-LAMBERT COMPANY (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0384320-A1 | Antihyperlipidemic and anti-atherosclerotic trisubstituted urea compounds | WARNER-LAMBERT COMPANY (US) | 1990-08-29 | — | — | EP | disclosed |