SCHEMBL9765049

SCHEMBL9765049

CCCCCCCN(CC1(c2ccccc2)CCCC1)C(=O)Nc1c(C(C)C)cccc1C(C)C

nearest known ligand 0.57

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SOAT2 O75908 1/20 0.48
ACAT1 P24752 1/20 0.48
SOAT1 P35610 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9765051 0.87 TP53 (0.43)
SCHEMBL9680743 0.84 SOAT1 (0.51) SOAT2ACAT1SOAT1
SCHEMBL9765050 0.84 SOAT1 (0.51) SOAT2ACAT1SOAT1
SCHEMBL9679685 0.79 SOAT1 (0.48) SOAT2ACAT1SOAT1
SCHEMBL6211611 0.78 SOAT1 (0.52) SOAT1
SCHEMBL9765041 0.77 SOAT1 (0.55) SOAT2ACAT1SOAT1
SCHEMBL9679702 0.76 SOAT1 (0.49) SOAT2ACAT1SOAT1
SCHEMBL6803071 0.75 UBE2M (0.46) SOAT2ACAT1SOAT1
SCHEMBL6808919 0.74 SOAT1 (0.50) SOAT2ACAT1SOAT1
SCHEMBL9679354 0.74 SOAT1 (0.47) SOAT2ACAT1SOAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4994465-A Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds WARNER-LAMBERT COMPANY (US) 1991-02-19 US disclosed
EP-0384320-A1 Antihyperlipidemic and anti-atherosclerotic trisubstituted urea compounds WARNER-LAMBERT COMPANY (US) 1990-08-29 EP disclosed