Sugi Predict

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SCHEMBL976537

SCHEMBL976537

CCOC(=O)c1cc(F)cc(N(C2CN(C(c3ccc(C(F)(F)F)cc3)c3ccc(C(F)(F)F)cc3)C2)S(C)(=O)=O)c1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 1/20 0.38
▸ SLC6A9 P48067 1/20 0.35
▸ BCHE P06276 2/20 0.35
▸ ACHE P22303 2/20 0.35
▸ MAOB P27338 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ MAPT P10636 3/20 0.34
▸ MMP2 P08253 1/20 0.34
▸ MMP9 P14780 1/20 0.34
▸ OPRD1 P41143 1/20 0.34
▸ ATM Q13315 1/20 0.34
▸ TP53 P04637 1/20 0.34
▸ CETP P11597 1/20 0.34
▸ THRB P10828 1/20 0.34
▸ TMEM97 Q5BJF2 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.33
▸ POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL978429 0.90 SLC6A9 (0.36) SLC6A9MEN1KMT2AMAPTOPRD1
SCHEMBL977037 0.90 MAPT (0.36) ALOX15KMT2AMAPTOPRD1TP53
SCHEMBL974854 0.90 OPRD1 (0.37) OPRD1
SCHEMBL977048 0.88 ELANE (0.37) KMT2AMAPTOPRD1NPSR1POLB
SCHEMBL975366 0.87 KCNH2 (0.36) SLC6A9MMP2MMP9OPRD1
SCHEMBL30961524 0.86 OPRD1 (0.47) SLC6A9MEN1KMT2AMAPTOPRD1
SCHEMBL30961564 0.86 OPRD1 (0.47) SLC6A9MEN1KMT2AMAPTOPRD1
SCHEMBL30961574 0.86 OPRD1 (0.47) SLC6A9MEN1KMT2AMAPTOPRD1
SCHEMBL979321 0.83 OPRD1 (0.35) SLC6A9MMP2MMP9OPRD1
SCHEMBL975371 0.82 MGLL (0.37) MEN1KMT2AMAPTOPRD1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI (FR) 2013-09-12 — — US claimed
EP-2234966-B1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI SA (FR) 2013-09-11 — — EP claimed
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI-AVENTIS (FR) 2011-01-13 — — US claimed
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI (FR) 2013-09-12 — — US disclosed
US-8445478-B2 Azetidine derivatives, their preparation and their application in therapy SANOFI (FR) 2013-05-21 — — US disclosed
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI-AVENTIS (FR) 2011-01-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY QDPR, AZI2, ADRA1B ALOX15 2801/4885SLC6A9 2158/4885BCHE 807/4885
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY QDPR, AZI2, ADRA1B ALOX15 2801/4885SLC6A9 2158/4885BCHE 807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.