Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9022900 | 0.73 | CYP2C19 (0.49) | EPHX2LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL29229 | 0.72 | LMNA (0.44) | EPHX2PPARGLMNAMAP3K14MEN1 | |
| SCHEMBL5776620 | 0.70 | MEN1 (0.42) | EPHX2PPARGLMNAMEN1ALDH1A1 | |
| SCHEMBL1607395 | 0.70 | CNR2 (0.57) | EPHX2LMNAMAP3K14ALDH1A1MAPT | |
| SCHEMBL27263180 | 0.69 | EPHX2 (0.49) | EPHX2PPARGLMNAMAP3K14PPARA | |
| SCHEMBL27263178 | 0.69 | DAO (0.40) | EPHX2PPARGLMNAMAP3K14MEN1 | |
| SCHEMBL11494952 | 0.69 | LMNA (0.41) | EPHX2PPARGLMNAMAP3K14PPARA | |
| SCHEMBL4600787 | 0.68 | PTGDR2 (0.41) | PPARGMEN1ALDH1A1KMT2AKDM4E | |
| Carbamic Acid SCHEMBL9006901 | 0.68 | ALOX5 (0.42) | MEN1ALDH1A1MAPTKMT2ACYP1A2 | |
| SCHEMBL1606849 | 0.67 | CNR2 (0.42) | LMNAMEN1ALDH1A1MAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022754-C | Novel aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds preparation method | MERRELL DOW PHARMA (US) | 1993-11-17 | — | — | CN | disclosed |
| US-5041554-A | Replace steroids in treatment of inflammatory diseases | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |
| US-5039695-A | Method of using aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds in the treatment of interleukin-1 mediated conditions | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-08-13 | — | — | US | disclosed |
| CN-1044653-A | The new aryl or the heteroaryl-I-alkyl-pyrroles-2-carboxylic acid that are used for the treatment of the pathological state of interleukin-I mediation | MERRELL DOW PHARMA (US) | 1990-08-15 | — | — | CN | disclosed |
| EP-0381141-A2 | Novel aryl- or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds useful in treating interleukin-1 mediated conditions | MERRELL PHARMACEUTICALS INC. (US) | 1990-08-08 | — | — | EP | disclosed |
| EP-0381142-A2 | Method of using aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds in the treatment of interleukin-1 mediated conditions | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-08-08 | — | — | EP | disclosed |