Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 1.00 |
| ▸ | DRD2 | P14416 | 7/20 | 0.81 |
| ▸ | DRD3 | P35462 | 6/20 | 0.81 |
| ▸ | HTR1A | P08908 | 5/20 | 0.81 |
| ▸ | HTR2A | P28223 | 5/20 | 0.81 |
| ▸ | DRD1 | P21728 | 4/20 | 0.81 |
| ▸ | DRD5 | P21918 | 4/20 | 0.81 |
| ▸ | HRH1 | P35367 | 2/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | HTR7 | P34969 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766026 | 0.81 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL11870245 | 0.78 | DRD2 (0.76) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL9765984 | 0.78 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL9602967 | 0.76 | SIGMAR1 (0.79) | SIGMAR1DRD2KDM4ECYP1A2GAA | |
| SCHEMBL9766043 | 0.76 | SIGMAR1 (0.82) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL7386166 | 0.76 | DRD2 (0.60) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL7855443 | 0.76 | SIGMAR1 (0.63) | SIGMAR1DRD2HTR1AKDM4ECYP1A2 | |
| SCHEMBL11868520 | 0.75 | DRD2 (0.64) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| Bmy-14802 SCHEMBL467229 | 0.75 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD3KDM4ECYP1A2 | |
| Bmy-14802 SCHEMBL8457738 | 0.75 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD3KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994460-A | Treatment or prevention of disorders resulting from central nervous system anoxia | BRISTOL-MYERS SQUIBB CO. (US) | 1991-02-19 | — | — | US | claimed |
| EP-0400661-A1 | Agents for treatment of brain ischemia | Bristol-Myers Squibb Company (US) | 1990-12-05 | — | — | EP | claimed |
| US-4994460-A | Treatment or prevention of disorders resulting from central nervous system anoxia | BRISTOL-MYERS SQUIBB CO. (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0400661-A1 | Agents for treatment of brain ischemia | Bristol-Myers Squibb Company (US) | 1990-12-05 | — | — | EP | disclosed |