Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD5 | P21918 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11818822 | 0.84 | DRD2 (0.39) | SIGMAR1SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL10854731 | 0.80 | CCR5 (0.39) | KCNH2GRIN1GRIN2BCHRM2HTR1A | |
| SCHEMBL7653024 | 0.78 | KDM4E (0.47) | SIGMAR1SLC6A4DRD2GRIN1GRIN2B | |
| SCHEMBL10507381 | 0.78 | MAPK1 (0.60) | SIGMAR1SLC6A3DRD2DRD1DRD5 | |
| SCHEMBL4054535 | 0.77 | CYP3A4 (0.43) | SLC6A2SLC6A4KCNH2SLC6A3GRIN1 | |
| SCHEMBL4053245 | 0.77 | MEN1 (0.41) | KCNH2KIF11DRD2GRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL9766048 | 0.77 | SIGMAR1 (0.57) | SIGMAR1DRD2HTR1A | |
| SCHEMBL7653473 | 0.76 | HTR7 (0.56) | SLC6A4DRD2GRIN1GRIN2BHTR1A | |
| SCHEMBL7297558 | 0.76 | CCR3 (0.53) | SIGMAR1SLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL11618780 | 0.76 | HTR2A (0.57) | SIGMAR1DRD2HTR2AHTR7HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796264-B2 | 2-piperazin-1-yl-4H-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2014-08-05 | — | — | US | disclosed |
| US-20130245007-A1 | 2-PIPERAZIN-1-YL-4H-1,3-BENZOTHIAZIN-4-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF MAMMALIAN INFECTIONS | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2013-09-19 | — | — | US | disclosed |
| US-4994460-A | Treatment or prevention of disorders resulting from central nervous system anoxia | BRISTOL-MYERS SQUIBB CO. (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0400661-A1 | Agents for treatment of brain ischemia | Bristol-Myers Squibb Company (US) | 1990-12-05 | — | — | EP | disclosed |
| US-4652565-A | NEUROLEPTIC, HYPOTENSIVE, BRADYCARDIC | SANDOZ LTD. (CH) | 1987-03-24 | — | — | US | disclosed |
| US-4588725-A | NEUROLEPTIC AGENTS; HYPOTENSIVE AGENTS | SANDOZ LTD. (CH) | 1986-05-13 | — | — | US | disclosed |
| US-4565816-A | HYPOTENSIVE, BRADYCARDIAL, NEUROLEPTIC | SANDOZ LTD. (CH) | 1986-01-21 | — | — | US | disclosed |
| WO-1983004254-A1 | PIPERAZINE DERIVATIVE COMPOUNDS, PRODUCTION METHOD THEREOF AND DRUGS CONTAINING THEM | SANDOZ AG (CH) | 1983-12-08 | — | — | WO | disclosed |
| US-3966735-A | CENTRAL NERVOUS SYSTEM | KALI-CHEMIE AKTIENGESELLSCHAFT (DT) | 1976-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245007-A1 | 2-PIPERAZIN-1-YL-4H-1,3-BENZOTHIAZIN-4-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF MAMMALIAN INFECTIONS | BPGM, TBC1D5, TBC1D15 | SIGMAR1 3391/4885SLC6A2 4853/4885SLC6A4 4844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.