Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.58 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766068 | 0.74 | SIGMAR1 (1.00) | SIGMAR1HTR1AGAADRD2HTR2A | |
| Ammonia Solution, Strong SCHEMBL9765999 | 0.73 | SIGMAR1 (0.98) | SIGMAR1HTR1AGAADRD2HTR2A | |
| SCHEMBL31585883 | 0.73 | ALDH1A1 (0.57) | SIGMAR1GAAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5362969 | 0.72 | HTR6 (0.65) | SIGMAR1HTR1ACYP2D6ALDH1A1HPGD | |
| SCHEMBL9766006 | 0.72 | SIGMAR1 (1.00) | SIGMAR1HTR1AGAADRD2KDM4E | |
| SCHEMBL9766069 | 0.71 | SIGMAR1 (0.67) | SIGMAR1HTR1AGAADRD2HTR2A | |
| SCHEMBL9766055 | 0.71 | SIGMAR1 (0.64) | SIGMAR1HTR1ACYP2D6GAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9766032 | 0.71 | SIGMAR1 (0.98) | SIGMAR1HTR1AGAADRD2KDM4E | |
| SCHEMBL24126297 | 0.68 | SIGMAR1 (0.46) | SIGMAR1HTR1ACYP2D6GAADRD2 | |
| SCHEMBL31585530 | 0.68 | ALDH1A1 (0.63) | GAAALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994460-A | Treatment or prevention of disorders resulting from central nervous system anoxia | BRISTOL-MYERS SQUIBB CO. (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0400661-A1 | Agents for treatment of brain ischemia | Bristol-Myers Squibb Company (US) | 1990-12-05 | — | — | EP | disclosed |