(Z)-1,2-Diphenylethene

(Z)-1,2-Diphenylethene

SCHEMBL9766302

C(=Cc1ccccc1)c1ccccc1.CCO.O=C(O)Cc1c([N+](=O)[O-])cc([N+](=O)[O-])cc1[N+](=O)[O-]

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of (Z)-1,2-Diphenylethene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.49
NFE2L2 Q16236 2/20 0.49
SMN1; SMN2 Q16637 4/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
RAB9A P51151 3/20 0.46
HPGD P15428 1/20 0.46
PTBP1 P26599 1/20 0.46
MAPT P10636 4/20 0.45
ALDH1A1 P00352 3/20 0.45
MAPK1 P28482 2/20 0.45
HTT P42858 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
CYP1B1 Q16678 1/20 0.44
TRPM8 Q7Z2W7 1/20 0.43
CYP19A1 P11511 1/20 0.41
MAOB P27338 2/20 0.41
BCHE P06276 1/20 0.41
KDM4E B2RXH2 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9292425 0.81 CYP1A2 (0.64) CYP1A2SMN1; SMN2MEN1KMT2AHPGD
SCHEMBL9766305 0.81 CYP1A2 (0.48) CYP1A2MEN1KMT2AMAPTALDH1A1
SCHEMBL10619763 0.76 CYP1A2 (0.58) CYP1A2MEN1KMT2AHPGDMAPT
SCHEMBL7918794 0.75 NFE2L2 (0.62) CYP1A2NFE2L2MEN1KMT2ARAB9A
SCHEMBL7918792 0.75 NFE2L2 (0.62) CYP1A2NFE2L2MEN1KMT2ARAB9A
SCHEMBL10617906 0.74 ALDH1A1 (0.57) CYP1A2MEN1KMT2AHPGDMAPT
(Z)-1,2-Diphenylethene SCHEMBL7260783 0.74 GPR35 (0.71) CYP1A2NFE2L2SMN1; SMN2MEN1KMT2A
SCHEMBL2711927 0.71 GPR35 (0.57) CYP1A2MEN1KMT2AHPGDMAPT
SCHEMBL2711921 0.71 GPR35 (0.57) CYP1A2MEN1KMT2AHPGDMAPT
SCHEMBL11797519 0.71 KMT2A (0.54) CYP1A2SMN1; SMN2MEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1991003683-A1 ACRYLIC COPOLYMERS EXHIBITING NONLINEAR OPTICAL RESPONSE HOECHST CELANESE CORP (US) 1991-03-21 WO disclosed