Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD3 | P35462 | 5/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9767412 | 0.87 | DRD2 (0.38) | DRD2DRD3KCNE1KCNQ1MEN1 | |
| SCHEMBL9766986 | 0.78 | KCNE1 (0.41) | DRD2DRD3KCNE1KCNQ1MEN1 | |
| SCHEMBL9766987 | 0.78 | KCNE1 (0.41) | DRD2DRD3KCNE1KCNQ1MEN1 | |
| SCHEMBL9767595 | 0.76 | ABCB1 (0.39) | DRD2DRD3ABCB1 | |
| SCHEMBL9767261 | 0.75 | MAOB (0.36) | DRD3MEN1KMT2A | |
| SCHEMBL9767073 | 0.68 | KCNE1 (0.43) | DRD2DRD3KCNE1KCNQ1MEN1 | |
| SCHEMBL6744381 | 0.66 | MAOB (0.52) | GRM2 | |
| SCHEMBL9767232 | 0.66 | KCNE1 (0.40) | DRD2DRD3KCNE1KCNQ1MEN1 | |
| SCHEMBL9767236 | 0.66 | KCNE1 (0.40) | DRD2DRD3KCNE1KCNQ1MEN1 | |
| SCHEMBL9765458 | 0.64 | ABCB1 (0.43) | KCNE1KCNQ1MEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5072006-A | Chemical intermeidate; hypotensive agents, muscle relaxants | RECHERCHE SYNTEX FRANCE S.A. (FR) | 1991-12-10 | — | — | US | disclosed |
| US-4997846-A | Smooth muscle relaxants, hypotensives | RESEARCHE SYNTEX FRANCE, S.A. (FR) | 1991-03-05 | — | — | US | disclosed |
| EP-0377966-A2 | Novel benzopyranylpyrrolinone derivatives | RECHERCHE SYNTEX FRANCE SA (FR) | 1990-07-18 | — | — | EP | disclosed |