Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.47 |
| ▸ | KDM6B | O15054 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9767604 | 0.80 | ALOX15 (0.51) | KDM4CKDM6BMKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL9191760 | 0.74 | ROCK1 (0.50) | MKNK1MKNK2SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL9193973 | 0.71 | ROCK1 (0.50) | MKNK1MKNK2SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL2580726 | 0.71 | PDE5A (0.62) | KDM4ENPSR1ALDH1A1MEN1KMT2A | |
| SCHEMBL16489591 | 0.70 | KDM4C (0.60) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL5752590 | 0.70 | TRPA1 (0.49) | MKNK1MKNK2SMN1; SMN2HDAC1ALDH1A1 | |
| SCHEMBL9785107 | 0.70 | KDM6B (0.48) | KDM4CKDM6BKDM4EMKNK1MKNK2 | |
| SCHEMBL26103577 | 0.70 | SMN1; SMN2 (0.48) | MKNK1MKNK2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL9196015 | 0.68 | ALDH1A1 (0.52) | KDM4CKDM4ESMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL11445253 | 0.68 | KCNQ2 (0.65) | SMN1; SMN2HTTNPSR1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992448-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | claimed |
| US-5037835-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0428878-A2 | Benzocycloalkylaminopyridinamines and related compounds, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4992448-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | disclosed |