Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24248160 | 0.87 | CES2 (0.32) | GPR84SPHK1FFAR1CES2LPAR1 | |
| SCHEMBL21500583 | 0.83 | ALDH1A1 (0.35) | SPHK1LMNAMAPTCYP2D6CES2 | |
| SCHEMBL25599928 | 0.83 | GPR84 (0.39) | GPR84SPHK1FFAR1LMNAMAPT | |
| SCHEMBL21500596 | 0.82 | — | — | |
| SCHEMBL1350818 | 0.80 | GPR84 (0.45) | GPR84SPHK1FFAR1LMNAMAPT | |
| SCHEMBL8532164 | 0.80 | GPR84 (0.45) | GPR84SPHK1FFAR1LMNAMAPT | |
| SCHEMBL9177080 | 0.80 | GPR84 (0.45) | GPR84SPHK1FFAR1LMNAMAPT | |
| SCHEMBL9173116 | 0.80 | GPR84 (0.45) | GPR84SPHK1FFAR1LMNAMAPT | |
| SCHEMBL9173507 | 0.80 | GPR84 (0.45) | GPR84SPHK1FFAR1LMNAMAPT | |
| SCHEMBL9175499 | 0.80 | GPR84 (0.45) | GPR84SPHK1FFAR1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057626-A | Difluoroketones from difluoroacylsilanes | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4996345-A | Difluoroketones from difluoroacylsilanes | PFIZER INC. (US) | 1991-02-26 | — | — | US | disclosed |