Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768289 | 0.86 | GRIN2B (0.57) | GRIN2BHTR1ADRD2HTR2AGRIA1 | |
| SCHEMBL8301786 | 0.75 | HTR1A (0.53) | GRIN2BHTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL8122268 | 0.73 | KCNH2 (0.67) | GRIN2BHTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL9768368 | 0.72 | GRIN2B (0.60) | GRIN2BHTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL8123895 | 0.71 | GRIN2B (0.74) | GRIN2BHTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL28574924 | 0.70 | HTR2A (0.64) | GRIN2BHTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL8549047 | 0.69 | GRIN1 (0.63) | GRIN2BADRA1DADRA1AADRA1B | |
| SCHEMBL15586812 | 0.69 | KCNH2 (0.57) | GRIN2BHTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL10838656 | 0.69 | GRIN2B (0.51) | GRIN2BHTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL29960317 | 0.69 | GRIN2B (0.56) | GRIN2BHTR1ADRD2HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5034401-A | Cardiovascular disorders or antiischemia agents | SYNTHELABO (FR) | 1991-07-23 | — | — | US | disclosed |