Cytosine

Cytosine

SCHEMBL9768402

Nc1cc[nH]c(=O)n1.O=P(O)(O)OP(=O)(O)OC1O[C@H](CO)[C@@H](O)[C@@H]1O

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
P2RY14 Q15391 9/20 0.45
P2RY6 Q15077 9/20 0.44
P2RY2 P41231 8/20 0.44
P2RY4 P51582 7/20 0.43
B4GALT1 P15291 1/20 0.43
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cytosine SCHEMBL672261 0.98 P2RY6 (0.46) P2RY14P2RY6P2RY2P2RY4B4GALT1
Cytosine SCHEMBL1687124 0.92 ALDH1A1 (0.44) P2RY14P2RY6P2RY2P2RY4ALDH1A1
Cytosine SCHEMBL11403996 0.82 PRKAG1 (0.33) P2RY6P2RY2P2RY4
Cytosine SCHEMBL3954369 0.79 P2RY2 (0.50) P2RY14P2RY6P2RY2P2RY4
Ribose (Furanose) SCHEMBL8833 0.79 LMNA (0.49) ALDH1A1
Ribose (Furanose) SCHEMBL3341287 0.79 LMNA (0.49) ALDH1A1
Ribose (Furanose) SCHEMBL2325834 0.79 LMNA (0.49) ALDH1A1
Ribose (Furanose) SCHEMBL142622 0.79 LMNA (0.49) ALDH1A1
SCHEMBL29656742 0.78 P2RY14 (0.47) P2RY14P2RY6P2RY2P2RY4B4GALT1
SCHEMBL3360274 0.78 P2RY14 (0.47) P2RY14P2RY6P2RY2P2RY4B4GALT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5043164-A Unsaturated phosphatidylethanolamine, micelle forming amphiphile THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) 1991-08-27 US claimed
US-20210196836-A1 FORMULATION OF NANOSTRUCTURED GELS FOR INCREASED AGENT LOADING AND ADHESION Alivio Therapeutics, Inc. 2021-07-01 US disclosed
US-10881745-B2 Formulation of nanostructured gels for increased agent loading and adhesion Alivio Therapeutics, Inc. (US) 2021-01-05 US disclosed
EP-3621594-A1 FORMULATION OF NANOSTRUCTURED GELS FOR INCREASED AGENT LOADING AND ADHESION Alivio Therapeutics, Inc. (US) 2020-03-18 EP disclosed
US-10300023-B1 Stabilized assembled nanostructures for delivery of encapsulated agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2019-05-28 US disclosed
EP-3452014-A1 SELF-ASSEMBLED GEL FOR CONTROLLED DELIVERY OF THERMOLABILE AGENTS The Brigham and Women's Hospital, Inc. (US) 2019-03-13 EP disclosed
WO-2018208822-A1 FORMULATION OF NANOSTRUCTURED GELS FOR INCREASED AGENT LOADING AND ADHESION Alivio Therapeutics, Inc. (US) 2018-11-15 WO disclosed
US-20180318442-A1 FORMULATION OF NANOSTRUCTURED GELS FOR INCREASED AGENT LOADING AND ADHESION Alivio Therapeutics, Inc. 2018-11-08 US disclosed
US-9962339-B2 Stabilized assembled nanostructures for delivery of encapsulated agents THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2018-05-08 US disclosed
US-20170319500-A1 SELF-ASSEMBLED GELS FOR CONTROLLED DELIVERY OF BIOLOGICS AND LABILE AGENTS UNITED STATES GOVERNMENT 2017-11-09 US disclosed
WO-2017193138-A1 SELF-ASSEMBLED GEL FOR CONTROLLED DELIVERY OF THERMOLABILE AGENTS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2017-11-09 WO disclosed
US-20170100342-A1 STABILIZED ASSEMBLED NANOSTRUCTURES FOR DELIVERY OF ENCAPSULATED AGENTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-04-13 US disclosed
WO-2017062818-A1 STABILIZED ASSEMBLED NANOSTRUCTURES FOR DELIVERY OF ENCAPSULATED AGENTS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2017-04-13 WO disclosed
US-5043164-A Unsaturated phosphatidylethanolamine, micelle forming amphiphile THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) 1991-08-27 US disclosed
US-5043164-A Unsaturated phosphatidylethanolamine, micelle forming amphiphile THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) 1991-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180318442-A1 FORMULATION OF NANOSTRUCTURED GELS FOR INCREASED AGENT LOADING AND ADHESION LTA, TMSB4X, TLN1 P2RY14 1660/4885P2RY6 604/4885P2RY2 1380/4885
US-10881745-B2 Formulation of nanostructured gels for increased agent loading and adhesion LTA, TMSB4X, TLN1 P2RY14 1660/4885P2RY6 604/4885P2RY2 1380/4885
US-20210196836-A1 FORMULATION OF NANOSTRUCTURED GELS FOR INCREASED AGENT LOADING AND ADHESION LTA, TMSB4X, TLN1 P2RY14 1660/4885P2RY6 604/4885P2RY2 1380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.