Sugi Predict

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SCHEMBL977237

SCHEMBL977237

COC(=O)c1cc(NS(=O)(=O)CC2CN(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)C2)cc(OC)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC6A9 P48067 1/20 0.37
▸ PDE4A P27815 1/20 0.37
▸ PDE4B Q07343 1/20 0.37
▸ PDE4C Q08493 1/20 0.37
▸ PDE4D Q08499 1/20 0.37
▸ ATM Q13315 1/20 0.37
▸ CNR2 P34972 1/20 0.37
▸ OPRD1 P41143 2/20 0.37
▸ LMNA P02545 2/20 0.36
▸ GPX4 P36969 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ MGLL Q99685 1/20 0.35
▸ CACNA1G O43497 1/20 0.35
▸ HPGD P15428 1/20 0.34
▸ UTS2R Q9UKP6 2/20 0.34
▸ ALPL P05186 1/20 0.34
▸ IDH1 O75874 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL977321 0.93 WDR5 (0.39) SLC6A9CNR2OPRD1LMNAGPX4
SCHEMBL975275 0.92 SLC6A9 (0.39) SLC6A9ATMOPRD1LMNAGPX4
SCHEMBL975711 0.89 SLC6A9 (0.37) SLC6A9ATMOPRD1LMNAGPX4
SCHEMBL977022 0.89 SLC6A9 (0.37) SLC6A9ATMOPRD1LMNAGPX4
SCHEMBL979165 0.88 SLC6A9 (0.36) SLC6A9ATMOPRD1LMNAGPX4
SCHEMBL976058 0.86 ATM (0.38) SLC6A9ATMCNR2UTS2R
SCHEMBL976314 0.86 MEN1 (0.35) CNR2LMNAMEN1ALDH1A1MAPT
SCHEMBL975372 0.84 KDM4E (0.41) ATMOPRD1LMNAMEN1ALDH1A1
SCHEMBL27965451 0.82 SLC6A9 (0.36) SLC6A9ATMOPRD1LMNAGPX4
SCHEMBL978430 0.81 HPGD (0.38) SLC6A9OPRD1LMNAMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI (FR) 2013-09-12 — — US claimed
EP-2234966-B1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI SA (FR) 2013-09-11 — — EP claimed
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI-AVENTIS (FR) 2011-01-13 — — US claimed
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI (FR) 2013-09-12 — — US disclosed
US-8445478-B2 Azetidine derivatives, their preparation and their application in therapy SANOFI (FR) 2013-05-21 — — US disclosed
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI-AVENTIS (FR) 2011-01-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY QDPR, AZI2, ADRA1B SLC6A9 2158/4885PDE4A 630/4885PDE4B 345/4885
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY QDPR, AZI2, ADRA1B SLC6A9 2158/4885PDE4A 630/4885PDE4B 345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.