Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 8/20 | 0.40 |
| ▸ | HRH1 | P35367 | 8/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404273 | 0.86 | ACE (0.53) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9775259 | 0.84 | ACE (0.51) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9773234 | 0.84 | CHRM2 (0.36) | ACEMEN1KMT2ACYP3A4TLR2 | |
| SCHEMBL9775457 | 0.82 | ACE (0.43) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9775310 | 0.81 | ACE (0.53) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9592654 | 0.80 | CTSL (0.54) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9773233 | 0.80 | CTSL (0.54) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9775231 | 0.80 | ACE (0.54) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9773200 | 0.80 | ACE (0.66) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL8755770 | 0.80 | CHRM2 (0.37) | ACEMEN1KMT2ACYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068242-A | PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE FOR PSYCHOTROPIC ACTION | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-11-26 | — | — | US | disclosed |
| US-4999370-A | ANXIOLYTIC AGENTS, INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME, NOOTROPIC AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-12 | — | — | US | disclosed |