Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936789 | 0.81 | ALDH1A1 (0.58) | KDM4EALDH1A1POLBKMT2ATDP1 | |
| SCHEMBL8445391 | 0.79 | ALDH1A1 (0.82) | KDM4EALDH1A1CYP1A2CYP3A4HTR1A | |
| SCHEMBL7289117 | 0.79 | DRD2 (0.63) | KDM4EALDH1A1CYP1A2CYP3A4HTR1A | |
| SCHEMBL4087689 | 0.78 | HTR1A (1.00) | KDM4EALDH1A1CYP1A2CYP3A4HTR1A | |
| SCHEMBL29389745 | 0.78 | HTR1A (1.00) | KDM4EALDH1A1CYP1A2CYP3A4HTR1A | |
| SCHEMBL2230435 | 0.78 | HTR1A (1.00) | KDM4EALDH1A1CYP1A2CYP3A4HTR1A | |
| SCHEMBL8445396 | 0.78 | CYP3A4 (0.56) | KDM4EALDH1A1CYP1A2CYP3A4HTR1A | |
| SCHEMBL25409013 | 0.78 | PKM (0.64) | KDM4EALDH1A1HTR1APOLBTDP1 | |
| Hydrochloric Acid SCHEMBL9992597 | 0.78 | ALDH1A1 (0.58) | KDM4EALDH1A1HTR1APOLBKMT2A | |
| Hydrochloric Acid SCHEMBL11867272 | 0.77 | DRD2 (0.61) | KDM4EALDH1A1CYP1A2CYP3A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988814-A | Antidepressants and/or anxiolytic agents | AMERICAN HOME PRODUCTS CORP. (US) | 1991-01-29 | — | — | US | claimed |
| US-4988814-A | Antidepressants and/or anxiolytic agents | AMERICAN HOME PRODUCTS CORP. (US) | 1991-01-29 | — | — | US | disclosed |