Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941932 | 0.92 | KMT2A (0.45) | KMT2AALDH1A1TSHRSTAT3KDM4E | |
| SCHEMBL9532522 | 0.87 | BAZ2B (0.48) | KMT2APOLBBAZ2BBAZ2AALDH1A1 | |
| SCHEMBL9775959 | 0.86 | ALDH1A1 (0.52) | KMT2APOLBALDH1A1TSHRKDM4E | |
| SCHEMBL9775979 | 0.86 | TOP2A (0.37) | KMT2APOLBALDH1A1KDM4EHPGD | |
| SCHEMBL501306 | 0.85 | KMT2A (0.46) | KMT2APOLBBAZ2BBAZ2AALDH1A1 | |
| SCHEMBL10390918 | 0.85 | BAZ2B (0.42) | KMT2APOLBBAZ2BBAZ2AALDH1A1 | |
| SCHEMBL9775880 | 0.84 | KMT2A (0.45) | KMT2APOLBBAZ2BBAZ2AALDH1A1 | |
| SCHEMBL9785255 | 0.83 | KMT2A (0.44) | KMT2APOLBALDH1A1TSHRKDM4E | |
| SCHEMBL9775866 | 0.83 | STAT3 (0.43) | KMT2AALDH1A1TSHRSTAT3KDM4E | |
| SCHEMBL7231247 | 0.83 | ADRB2 (0.46) | KMT2APOLBBAZ2BBAZ2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |