Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775959 | 0.92 | ALDH1A1 (0.52) | KMT2AALDH1A1TSHRPOLBMAPK1 | |
| SCHEMBL9786163 | 0.92 | KMT2A (0.50) | KMT2AALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL9785255 | 0.89 | KMT2A (0.44) | KMT2AALDH1A1TSHRPOLBMAPK1 | |
| SCHEMBL9532522 | 0.89 | BAZ2B (0.48) | KMT2AALDH1A1TSHRPOLBBAZ2B | |
| SCHEMBL9775919 | 0.86 | LMNA (0.43) | KMT2AALDH1A1TSHRLMNAMEN1 | |
| SCHEMBL9775895 | 0.84 | KMT2A (0.40) | KMT2AALDH1A1TSHRPOLBBAZ2B | |
| SCHEMBL8941946 | 0.83 | ALDH1A1 (0.55) | KMT2AALDH1A1TSHRPOLBMAPK1 | |
| SCHEMBL9786144 | 0.83 | KMT2A (0.47) | KMT2AALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL7231247 | 0.83 | ADRB2 (0.46) | KMT2AALDH1A1TSHRPOLBBAZ2B | |
| SCHEMBL9776043 | 0.81 | KMT2A (0.40) | KMT2AALDH1A1TSHRPOLBBAZ2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |