Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 4/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775895 | 0.86 | KMT2A (0.40) | TOP2ATOP2BLMNAKMT2AMEN1 | |
| SCHEMBL7230355 | 0.85 | LMNA (0.39) | TOP2ATOP2BCYP2C9LMNAATP6V1B2 | |
| SCHEMBL7235145 | 0.83 | CYP2C9 (0.37) | TOP2ATOP2BCYP2C9LMNAATP6V1B2 | |
| SCHEMBL5874071 | 0.82 | KEAP1 (0.46) | TOP2ATOP2BCYP2C9LMNAATP6V1B2 | |
| SCHEMBL7229905 | 0.82 | LMNA (0.55) | CYP2C9LMNAATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775919 | 0.80 | LMNA (0.43) | CYP2C9LMNAATP6V1B2TBXA2REDNRA | |
| SCHEMBL8942226 | 0.80 | KMT2A (0.46) | TOP2ATOP2BCYP2C9LMNAATP6V1B2 | |
| SCHEMBL9775916 | 0.80 | ALDH1A1 (0.52) | TOP2ATOP2BCYP2C9LMNAATP6V1B2 | |
| SCHEMBL6603661 | 0.79 | DPP4 (0.53) | TOP2ATOP2BCYP2C9LMNADPP4 | |
| SCHEMBL8942165 | 0.79 | EPHA2 (0.37) | TOP2ATOP2BCYP2C9LMNAATP6V1B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |