Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786233 | 0.91 | LMNA (0.46) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL7229905 | 0.89 | LMNA (0.55) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775880 | 0.86 | KMT2A (0.45) | LMNAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7230355 | 0.85 | LMNA (0.39) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9785206 | 0.84 | LMNA (0.44) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL28331885 | 0.82 | KDM4E (0.52) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL7235145 | 0.81 | CYP2C9 (0.37) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775969 | 0.81 | ALDH1A1 (0.67) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775979 | 0.80 | TOP2A (0.37) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL8942028 | 0.79 | LMNA (0.59) | LMNACYP2C9ATP6V1B2TBXA2REDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |