Sugi Predict

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SCHEMBL7235145

SCHEMBL7235145

CNn1cc(C(=O)O)c(=O)c2cc3cc(F)c(Cl)cc3nc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP2C9 P11712 3/20 0.37
▸ LMNA P02545 3/20 0.37
▸ ATP6V1B2 P21281 1/20 0.37
▸ TBXA2R P21731 1/20 0.37
▸ EDNRA P25101 1/20 0.37
▸ TARBP2 Q15633 1/20 0.37
▸ DPP4 P27487 1/20 0.35
▸ EGLN1 Q9GZT9 1/20 0.34
▸ CYP3A4 P08684 2/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ XBP1 P17861 1/20 0.34
▸ NFKB1 P19838 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ NFKB2 Q00653 1/20 0.34
▸ RELA Q04206 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ KMT2A Q03164 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7230355 0.86 LMNA (0.39) CYP2C9LMNAATP6V1B2TBXA2REDNRA
SCHEMBL9775979 0.83 TOP2A (0.37) CYP2C9LMNAATP6V1B2TBXA2REDNRA
SCHEMBL7229905 0.83 LMNA (0.55) CYP2C9LMNAATP6V1B2TBXA2REDNRA
SCHEMBL9775907 0.81 ALDH1A1 (0.52) LMNAKDM4EALDH1A1HPGDHTT
SCHEMBL9775919 0.81 LMNA (0.43) CYP2C9LMNAATP6V1B2TBXA2REDNRA
SCHEMBL8942031 0.81 KMT2A (0.46) CYP2C9LMNAATP6V1B2TBXA2REDNRA
SCHEMBL9775863 0.81 ALDH1A1 (0.52) CYP2C9LMNAATP6V1B2TBXA2REDNRA
SCHEMBL8942041 0.81 TOP1 (0.42) CYP2C9LMNAATP6V1B2TBXA2REDNRA
SCHEMBL6603661 0.80 DPP4 (0.53) CYP2C9LMNADPP4KDM4EALDH1A1
SCHEMBL8941986 0.80 ALDH1A1 (0.38) CYP2C9LMNAATP6V1B2TBXA2REDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6548506-B2 1-substituted,3-carboxy,7-fluoro,8-disubstituted amino-1,4-dihydrobenzo(b)(1,8)naphthyridin-4-ones; Useful as antimicrobial agents; topical antibiotic for wounds AVENTIS PHARMA S.A. (FR) 2003-04-15 — — US disclosed
US-20020037891-A1 Novel benzo[1,8]naphthyridine derivatives, their preparation and pharmaceutical compositions which comprise them AVENTIS PHARMA S.A. (FR) 2002-03-28 — — US disclosed
US-5004745-A Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them LABORATOIRE ROGER BELLON (FR) 1991-04-02 — — US disclosed
US-4990515-A Chemical intermediates RHONE-POULENC SANTE (FR) 1991-02-05 — — US disclosed
US-4970213-A Benzo(1,8)naphthyridine derivatives as intermediates RHONE-POULENC SANTE (FR) 1990-11-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020037891-A1 Novel benzo[1,8]naphthyridine derivatives, their preparation and pharmaceutical compositions which comprise them ABCB11, NDUFA9, NDUFC1 CYP2C9 111/4885LMNA 1363/4885ATP6V1B2 1314/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.