SCHEMBL9777384

SCHEMBL9777384

Cc1c(Cl)cc(C(C)(C)C)c(C(C)(C)C)c1Cl

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.47
TP53 P04637 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
HIF1A Q16665 1/20 0.47
ALDH1A1 P00352 2/20 0.32
CA2 P00918 1/20 0.32
POLB P06746 1/20 0.32
TYR P14679 1/20 0.32
KDM4E B2RXH2 1/20 0.31
CYP1A2 P05177 1/20 0.31
MAPT P10636 1/20 0.31
ALOX15 P16050 1/20 0.31
ATP2A2 P16615 1/20 0.31
ATP2A3 Q93084 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10824250 0.83 SMN1; SMN2 (0.43) SMN1; SMN2TP53CYP2C9CYP2C19HIF1A
SCHEMBL28063692 0.82 SMN1; SMN2 (0.50) SMN1; SMN2TP53CYP2C9CYP2C19HIF1A
SCHEMBL31519178 0.82 TP53 (0.37) SMN1; SMN2TP53CYP2C9CYP2C19HIF1A
SCHEMBL28419778 0.77 SMN1; SMN2 (0.37) SMN1; SMN2TP53CYP2C9CYP2C19HIF1A
SCHEMBL10488673 0.77 SMN1; SMN2 (0.65) SMN1; SMN2TP53CYP2C9CYP2C19HIF1A
SCHEMBL10824253 0.76 ALOX15 (0.36) SMN1; SMN2TP53CYP2C9CYP2C19HIF1A
SCHEMBL27962109 0.75 SMN1; SMN2 (0.62) SMN1; SMN2TP53CYP2C9CYP2C19HIF1A
SCHEMBL20393330 0.71 CYP3A4 (0.36) SMN1; SMN2TP53CYP2C9CYP2C19HIF1A
SCHEMBL27883056 0.71 SMN1; SMN2 (0.53) SMN1; SMN2TP53CYP2C9CYP2C19HIF1A
SCHEMBL24910469 0.70 SMN1; SMN2 (0.45) SMN1; SMN2TP53CYP2C9CYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3031229-A None JP disclosed
JP-H0331229-A PRODUCTION OF 2,6-DICHLOROTOLUENE IDEMITSU KOSAN CO LTD 1991-02-12 JP disclosed