SCHEMBL28063692

SCHEMBL28063692

Cc1c(Cl)cc(C(C)(C)C)c(Cl)c1Cl

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.50
CYP2C9 P11712 2/20 0.50
CYP2C19 P33261 2/20 0.50
TP53 P04637 1/20 0.50
HIF1A Q16665 1/20 0.50
ALDH1A1 P00352 2/20 0.34
CA2 P00918 2/20 0.34
POLB P06746 1/20 0.34
TYR P14679 1/20 0.34
CYP1A2 P05177 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPT P10636 1/20 0.33
ALOX15 P16050 1/20 0.33
ATP2A2 P16615 1/20 0.33
ATP2A3 Q93084 1/20 0.33
CA1 P00915 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9777384 0.82 SMN1; SMN2 (0.47) SMN1; SMN2CYP2C9CYP2C19TP53HIF1A
SCHEMBL1764669 0.81 TSHR (0.38) SMN1; SMN2CYP2C9CYP2C19TP53HIF1A
SCHEMBL10488673 0.80 SMN1; SMN2 (0.65) SMN1; SMN2CYP2C9CYP2C19TP53HIF1A
SCHEMBL7855792 0.79 TP53 (0.36) SMN1; SMN2CYP2C9CYP2C19TP53HIF1A
SCHEMBL7098338 0.77 TP53 (0.39) SMN1; SMN2CYP2C9CYP2C19TP53HIF1A
SCHEMBL7903146 0.77 TP53 (0.35) SMN1; SMN2CYP2C9CYP2C19TP53HIF1A
SCHEMBL937606 0.77 TP53 (0.35) SMN1; SMN2CYP2C9CYP2C19TP53HIF1A
SCHEMBL7926904 0.77 SMN1; SMN2 (0.41) SMN1; SMN2CYP2C9CYP2C19TP53HIF1A
SCHEMBL18272106 0.74 TP53 (0.33) SMN1; SMN2CYP2C9CYP2C19TP53HIF1A
SCHEMBL24910469 0.73 SMN1; SMN2 (0.45) SMN1; SMN2CYP2C9CYP2C19TP53HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105461541-A A preparing method of 2-methoxy-3,6-dichlorobenzoic acid JIANGSU LIANHE CHEMICAL TECH CO LTD 2016-04-06 CN disclosed