Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 13/20 | 0.63 |
| ▸ | HTR1A | P08908 | 3/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MLNR | O43193 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9778482 | 0.86 | HTR7 (0.70) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9778474 | 0.80 | HTR7 (0.60) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL8126688 | 0.80 | HTR7 (0.74) | HTR7HTR1AADORA3CHRM1SLC6A4 | |
| SCHEMBL9854895 | 0.79 | HTR7 (0.38) | HTR7HTR1ADRD2LMNAOPRM1 | |
| SCHEMBL9778428 | 0.78 | HTR1A (0.52) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL8128438 | 0.78 | HTR7 (1.00) | HTR7HTR1ADRD2MEN1ADRA2C | |
| SCHEMBL11222646 | 0.78 | HTR1A (0.66) | HTR7HTR1ADRD2HTR2AHTR6 | |
| Hydrochloric Acid SCHEMBL11036620 | 0.77 | HTR1A (0.65) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL8943310 | 0.76 | HTR7 (0.81) | HTR7HTR1ADRD2ADRA2CDRD3 | |
| SCHEMBL9541502 | 0.76 | HTR1A (0.71) | HTR7HTR1ADRD2HTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4954503-A | ANALGESIC, ANTIPSYCHOTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-09-04 | — | — | US | claimed |
| US-5077405-A | Condensation of corresponding phenylsulfonyl compound with condensation agent, cyanation, reduction | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-12-31 | — | — | US | disclosed |
| EP-0417653-A1 | 3-(1-Substituted-4-piperazinyl)-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4954503-A | ANALGESIC, ANTIPSYCHOTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-09-04 | — | — | US | disclosed |