Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9779268 | 1.00 | SCN9A (0.45) | SCN9ALMNAKMT2ACD274ALDH1A1 | |
| SCHEMBL9779277 | 0.95 | SCN9A (0.48) | SCN9ALMNAKMT2ACD274ALDH1A1 | |
| Fumaric Acid SCHEMBL10430887 | 0.83 | ALDH1A1 (0.41) | KMT2AALDH1A1CYP1A2LRRK2KDM4E | |
| SCHEMBL9779422 | 0.81 | LMNA (0.49) | LMNAKMT2AALDH1A1MAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9779325 | 0.80 | LMNA (0.48) | LMNAKMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL9779369 | 0.80 | ALDH1A1 (0.51) | LMNAKMT2ACD274ALDH1A1USP2 | |
| SCHEMBL9779267 | 0.80 | CD274 (0.52) | SCN9ALMNAKMT2ACD274ALDH1A1 | |
| SCHEMBL9779236 | 0.77 | ALDH1A1 (0.48) | LMNAKMT2AALDH1A1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL9779394 | 0.76 | ALDH1A1 (0.51) | LMNAKMT2ACD274ALDH1A1USP2 | |
| SCHEMBL9779476 | 0.76 | CD274 (0.48) | SCN9ACD274ALDH1A1USP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037824-A | Cardiotonic, antiischemic agents | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1991-08-06 | — | — | US | disclosed |
| EP-0387070-A2 | N-Containing heterocyclic compounds, processes for the preparation thereof and composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-09-12 | — | — | EP | disclosed |