Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 2/20 | 0.42 |
| ▸ | ATP4B | P51164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10493567 | 0.81 | ATP4A (0.41) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL10382949 | 0.79 | CYP4F2 (0.47) | HTR1AMAOBDRD2 | |
| Hydrochloric Acid SCHEMBL9786007 | 0.78 | LTA4H (0.45) | MAPK14GAAHTR1ADRD2AOC3 | |
| SCHEMBL8248932 | 0.77 | BCHE (0.48) | MAPTL3MBTL1HTR1AADRA1DADRA1A | |
| SCHEMBL28374136 | 0.75 | ALDH1A1 (0.46) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL17583875 | 0.75 | ABCB1 (0.53) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL31681740 | 0.75 | BCHE (0.46) | ATP4AATP4BMAPTL3MBTL1HTR1A | |
| SCHEMBL3150720 | 0.75 | HTR1A (0.61) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL9379558 | 0.73 | MAPK1 (0.47) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL6034592 | 0.72 | BCHE (0.63) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023378-A | Hypotensive agents, antiischemic agents, urogenital disorders | GLAXO GROUP LIMITED (GB) | 1991-06-11 | — | — | US | disclosed |
| EP-0188361-B1 | AMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-03-06 | — | — | EP | disclosed |
| EP-0188361-A1 | Amine derivatives | GLAXO GROUP LIMITED (GB) | 1986-07-23 | — | — | EP | disclosed |