Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ATP4A | P20648 | 1/20 | 0.50 |
| ▸ | ATP4B | P51164 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13009607 | 0.94 | HTR1A (0.68) | HTR1ADRD2ABCB1GAAMAPK1 | |
| SCHEMBL2994273 | 0.90 | CARM1 (0.51) | HTR1ADRD2ABCB1GAAMAPK1 | |
| SCHEMBL3999884 | 0.85 | DRD2 (0.53) | HTR1ADRD2ABCB1GAAMAPK1 | |
| SCHEMBL31482951 | 0.84 | L3MBTL1 (0.48) | HTR1ADRD2ABCB1GAAMAPK1 | |
| SCHEMBL28104163 | 0.84 | FFAR1 (0.45) | HTR1ADRD2MAPK1MAPTTDP1 | |
| SCHEMBL22357315 | 0.84 | L3MBTL1 (0.48) | HTR1ADRD2ABCB1GAAMAPK1 | |
| SCHEMBL17583875 | 0.83 | ABCB1 (0.53) | HTR1ADRD2ABCB1MAPK1MAPT | |
| SCHEMBL3178663 | 0.83 | HTR1A (0.67) | HTR1ADRD2ABCB1GAAMAPK1 | |
| SCHEMBL3819411 | 0.82 | MAOB (0.55) | GAAMAPTL3MBTL1CYP1A2HDAC6 | |
| SCHEMBL7123270 | 0.82 | HTR1A (0.61) | HTR1ADRD2ABCB1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304578-B2 | Process for producing 1-[2-(dimethylamino)-1-(4-phenol)ethyl]cyclohexanol | MATRIX LABORATORIES LIMITED (IN) | 2012-11-06 | — | — | US | claimed |
| US-20100286447-A1 | PROCESS FOR PRODUCING 1-[2-(DIMETHYLAMINO)-1-(4-PHENOL)ETHYL]CYCLOHEXANOL | MATRIX LABORATORIES LIMITED (IN) | 2010-11-11 | — | — | US | claimed |
| WO-2009084039-A2 | PROCESS FOR PRODUCING 1-[2-(DIMETHYLAMINO)-1-(4-PHENOL)ETHYL]CYCLOHEXANOL | MATRIX LABORATORIES LIMITED (IN) | 2009-07-09 | — | — | WO | claimed |
| WO-2025016469-A1 | ALKOXY THIOPHENE ACYL ARYLAMINE COMPOUNDS AND USE THEREOF | 复旦大学 | 2025-01-23 | — | — | WO | disclosed |
| CN-119320385-A | Alkoxy thiophene carboxamide compounds and application thereof | 复旦大学 | 2025-01-17 | — | — | CN | disclosed |
| EP-2488028-B1 | SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF | MERCK SHARP & DOHME (US) | 2020-08-19 | — | — | EP | disclosed |
| US-20140336222-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | MERCK SHARP & DOHME (US) | 2014-11-13 | — | — | US | disclosed |
| US-8859776-B2 | Substituted piperidines that increase p53 activity and the uses thereof | MERCK SHARP & DOHME CORP. (US) | 2014-10-14 | — | — | US | disclosed |
| US-8304578-B2 | Process for producing 1-[2-(dimethylamino)-1-(4-phenol)ethyl]cyclohexanol | MATRIX LABORATORIES LIMITED (IN) | 2012-11-06 | — | — | US | disclosed |
| WO-2011046771-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | SCHERING CORPORATION (US) | 2011-04-21 | — | — | WO | disclosed |
| US-20100286447-A1 | PROCESS FOR PRODUCING 1-[2-(DIMETHYLAMINO)-1-(4-PHENOL)ETHYL]CYCLOHEXANOL | MATRIX LABORATORIES LIMITED (IN) | 2010-11-11 | — | — | US | disclosed |
| US-20050267119-A1 | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions | BRISTOL-MYERS SQUIBB COMPANY | 2005-12-01 | — | — | US | disclosed |
| WO-2005113511-A1 | UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20030114502-A1 | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-06-19 | — | — | US | disclosed |
| WO-2003006015-A1 | SUBSTITUTED THIAZOLES AND OXAZOLES AS CORTICOTROPIN RELEASING HORMONE LIGANDS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2003-01-23 | — | — | WO | disclosed |
| EP-1087940-A1 | NOVEL COMPOUNDS USEFUL IN PAIN MANAGEMENT | AstraZeneca AB (SE) | 2001-04-04 | — | — | EP | disclosed |
| US-6017919-A | Compounds and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2000-01-25 | — | — | US | disclosed |
| WO-1999067203-A1 | NOVEL COMPOUNDS USEFUL IN PAIN MANAGEMENT | ASTRAZENECA AB (SE) | 1999-12-29 | — | — | WO | disclosed |
| EP-0887340-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL USE THEREOF | Japan Tobacco Inc. (JP) | 1998-12-30 | — | — | EP | disclosed |
| US-4412082-A | Method for preparing 4-hydroxyphenylacetic acid | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1983-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114502-A1 | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands | CRH, CRHR1, CRHR2 | HTR1A 61/4885DRD2 287/4885ABCB1 3699/4885 |
| US-20100286447-A1 | PROCESS FOR PRODUCING 1-[2-(DIMETHYLAMINO)-1-(4-PHENOL)ETHYL]CYCLOHEXANOL | COMT, HTR1A, TPH1 | HTR1A 2/4885DRD2 62/4885ABCB1 2125/4885 |
| US-20050267119-A1 | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions | P2RY1, P2RY11, P2RY2 | HTR1A 190/4885DRD2 3691/4885ABCB1 873/4885 |
| US-20140336222-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | TP53, TP53BP1, MDM2 | HTR1A 3528/4885DRD2 4173/4885ABCB1 1149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.