SCHEMBL9787166

SCHEMBL9787166

Fc1nc(F)c(Cl)c(Cl)c1Cl

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
GAA P10253 1/20 0.32
KMT2A Q03164 1/20 0.32
ALDH1A1 P00352 1/20 0.31
ALOX15 P16050 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9850287 0.87
SCHEMBL8007054 0.83
SCHEMBL10744284 0.83 MEN1 (0.37) MEN1GAAKMT2A
SCHEMBL282140 0.81 MEN1 (0.35) MEN1GAAKMT2A
SCHEMBL9513607 0.79 MEN1 (0.34) MEN1GAAKMT2A
SCHEMBL134038 0.76 HPGD (0.44) MEN1KMT2AALDH1A1TSHR
SCHEMBL502245 0.76 MEN1 (0.37) MEN1GAAKMT2A
SCHEMBL3569028 0.76 MEN1 (0.37) MEN1GAAKMT2A
SCHEMBL8114120 0.76
SCHEMBL7028015 0.74 MEN1 (0.36) MEN1GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4999432-A Heating and dechlorination of a chloropyridine DOWELANCO (US) 1991-03-12 US claimed
EP-0415498-A2 Fluorination with hydrogen fluoride DOWELANCO (US) 1991-03-06 EP claimed
US-4542221-A Exchanging fluorine for chlorine in a chlorinated pyridine with an alkali metal fluoride THE DOW CHEMICAL COMPANY (US) 1985-09-17 US claimed
US-4999432-A Heating and dechlorination of a chloropyridine DOWELANCO (US) 1991-03-12 US disclosed
EP-0415498-A2 Fluorination with hydrogen fluoride DOWELANCO (US) 1991-03-06 EP disclosed
US-4542221-A Exchanging fluorine for chlorine in a chlorinated pyridine with an alkali metal fluoride THE DOW CHEMICAL COMPANY (US) 1985-09-17 US disclosed